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With the concept a more speedy cell cycle is really a vital part of pluripotency, reprogramming efficiency can be improved. Methods for bettering pluripotency through manipulation of cell cycle regulators consist of: overexpression of Cyclin D/Cdk4, phosphorylation of Sox2 at S39 and S253, overexpression of Cyclin A and Cyclin E, knockdown of Rb, a
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